TRP channels in normal and dystrophic skeletal muscle

Highlights ► TRP proteins constitute non-selective calcium-permeable channels. ► The most consistently found isoforms in skeletal muscle are TRPC1, C3, C6, TRPV2 and V4, TRPM4 and M7. ► In this review, we discuss the gating mechanisms of these TRP channels, their pharmacological profiles and their f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in pharmacology 2012-06, Vol.12 (3), p.326-334
1. Verfasser:	Gailly, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Excitation Contraction Coupling Humans Internal Medicine Medical Education Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Muscular Dystrophies - metabolism Transient Receptor Potential Channels - metabolism TRPM Cation Channels - metabolism TRPV Cation Channels - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► TRP proteins constitute non-selective calcium-permeable channels. ► The most consistently found isoforms in skeletal muscle are TRPC1, C3, C6, TRPV2 and V4, TRPM4 and M7. ► In this review, we discuss the gating mechanisms of these TRP channels, their pharmacological profiles and their functions in normal muscle. ► Their possible involvement in Duchenne muscular dystrophy is also summarized.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2012.01.018