Trehalose glycolipids—synthesis and biological activities

A variety of trehalose glycolipids have been isolated from natural sources, and several of these glycolipids exhibit important biological properties. These molecules also represent challenging synthetic targets due to their highly amphiphilic character, their large number of functional groups and ad...

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Veröffentlicht in:	Carbohydrate research 2012-07, Vol.356, p.25-36
Hauptverfasser:	Khan, Ashna A., Stocker, Bridget L., Timmer, Mattie S.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	6,6′-Diesters Animals Bacteria bioactive properties Biological activity Caenorhabditis elegans Carbohydrate Conformation Cell Line, Tumor Cell Survival - drug effects Chemical synthesis Cytokines - biosynthesis Esters glycolipids Glycolipids - chemistry Glycolipids - isolation & purification Glycolipids - pharmacology Humans Macrophages - drug effects Macrophages - metabolism Neoplasms - drug therapy Neoplasms - metabolism Nitric Oxide - biosynthesis Sulfoglycolipids Surface-Active Agents - chemistry Surface-Active Agents - isolation & purification Surface-Active Agents - pharmacology trehalose Trehalose - chemistry Trehalose - isolation & purification Trehalose - pharmacology Trehalose glycolipids
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Beschreibung
Zusammenfassung:	A variety of trehalose glycolipids have been isolated from natural sources, and several of these glycolipids exhibit important biological properties. These molecules also represent challenging synthetic targets due to their highly amphiphilic character, their large number of functional groups and additional chiral centres. This review highlights some of the recent advances made in the synthesis of trehalose glycolipids, and their associated biological activities.
ISSN:	0008-6215 1873-426X
DOI:	10.1016/j.carres.2012.03.010