Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial

Summary The Medical Research Council Acute Myeloid Leukaemia 12 (MRC AML12) trial (children) addressed the optimal anthracenedione/anthracycline in induction and the optimal number of courses of consolidation chemotherapy. 504 children (

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Veröffentlicht in:	British journal of haematology 2011-11, Vol.155 (3), p.366-376
Hauptverfasser:	Gibson, Brenda E. S., Webb, David K. H., Howman, Andrew J., De Graaf, Siebold S. N., Harrison, Christine J., Wheatley, Keith
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent AML Anthracycline Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Child Child, Preschool childhood leukaemia Children clinical trial Consolidation Chemotherapy cytarabine Cytarabine - administration & dosage Daunorubicin Daunorubicin - administration & dosage Disease-Free Survival Etoposide Etoposide - administration & dosage Female Hematologic and hematopoietic diseases Humans Induction Chemotherapy Infant Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences mitoxantrone Mitoxantrone - administration & dosage myeloid leukaemia Prognosis Remission Survival Survival Analysis therapy Thioguanine - administration & dosage Treatment Outcome
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Beschreibung
Zusammenfassung:	Summary The Medical Research Council Acute Myeloid Leukaemia 12 (MRC AML12) trial (children) addressed the optimal anthracenedione/anthracycline in induction and the optimal number of courses of consolidation chemotherapy. 504 children (
ISSN:	0007-1048 1365-2141
DOI:	10.1111/j.1365-2141.2011.08851.x