Incidence of bacteremias and invasive mycoses in children with acute non-lymphoblastic leukemia: Results from a multi-center Italian study

Background Data on the epidemiology of bacteremias and invasive fungal diseases (IFD) in children with acute myeloid leukemia (AML) are scarce. Design and Methods In a multi‐center, retrospective study, we analyzed proportion, rate per 1,000 person‐days at risk, and cumulative risk of bacteremias an...

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Veröffentlicht in:	Pediatric blood & cancer 2010-12, Vol.55 (6), p.1103-1107
Hauptverfasser:	Castagnola, Elio, Rossi, Mario R., Cesaro, Simone, Livadiotti, Susanna, Giacchino, Mareva, Zanazzo, Giulio, Fioredda, Francesca, Beretta, Chiara, Ciocchello, Francesca, Carli, Modesto, Putti, Maria Caterina, Pansini, Valeria, Berger, Massimo, Licciardello, Maria, Farina, Silvia, Caviglia, Ilaria, Haupt, Riccardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia acute non-lymphoblastic leukemia Antineoplastic Combined Chemotherapy Protocols - adverse effects Bacteremia Bacteremia - etiology Bacteremia - pathology Blood Cancer Child Children Data processing Epidemiology Female Follow-Up Studies Humans Incidence invasive mycosis Invasiveness Italy Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - microbiology Male Mycoses - etiology Mycoses - pathology Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - microbiology Pediatrics Retrospective Studies Statistical analysis
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Zusammenfassung:	Background Data on the epidemiology of bacteremias and invasive fungal diseases (IFD) in children with acute myeloid leukemia (AML) are scarce. Design and Methods In a multi‐center, retrospective study, we analyzed proportion, rate per 1,000 person‐days at risk, and cumulative risk of bacteremias and IFD in children with AML. Results Between January 1998 and December 2005, 240 children were treated for AML at 8 Italian Centers, for a total of 521 treatment courses and 63,232 person‐days at risk. Bacteremia was observed in 32% of treatment courses and IFD was seen in 10% (P
ISSN:	1545-5009 1545-5017 1545-5017
DOI:	10.1002/pbc.22750