The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status

A Caenorhabditis elegans insulin-like signaling pathway regulates development, metabolism, and longevity. We detected abundant DAF-2 insulin-like receptor protein mainly in the nervous system, consistent with the assignment of DAF-2 pathway regulation of longevity to the nervous system. DAF-2 abunda...

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Veröffentlicht in:	Cold Spring Harbor Symposia on Quantitative Biology 2011, Vol.76, p.113-120
Hauptverfasser:	Kimura, K D, Riddle, D L, Ruvkun, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Down-Regulation Environment Mutation - genetics Nervous System - metabolism Neurons - cytology Neurons - metabolism Nutritional Physiological Phenomena Protein Transport Receptor, Insulin - genetics Receptor, Insulin - metabolism Signal Transduction
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Zusammenfassung:	A Caenorhabditis elegans insulin-like signaling pathway regulates development, metabolism, and longevity. We detected abundant DAF-2 insulin-like receptor protein mainly in the nervous system, consistent with the assignment of DAF-2 pathway regulation of longevity to the nervous system. DAF-2 abundance in the nervous system is dependent on food intake, showing environmental modulation of pathway signaling. DAF-2 abundance is not dependent on downstream PI-3 kinase to DAF-16 transcription factor signaling. The modulation of DAF-2 protein level by nutritional status may constitute an important component in the irreversible commitment to dauer arrest.
ISSN:	0091-7451 1943-4456
DOI:	10.1101/sqb.2011.76.010660