A Comprehensive History of Arynes in Natural Product Total Synthesis

A Comprehensive History of Arynes in Natural Product Total Synthesis

An examination of the history of the complete chemical synthesis of arynes, an uncharged reactive intermediate derived from an aromatic system, is presented. Arynes rapidly activate an aromatic ring by forming multiple carbon-carbon bonds, and the synthesis of natural products are dependent upon nuc...

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Veröffentlicht in:Chemical reviews 2012-06, Vol.112 (6), p.3550-3577
Hauptverfasser: Tadross, Pamela M, Stoltz, Brian M
Format: Artikel
Sprache:eng
Schlagworte:
Biological Products - chemical synthesis
Biological Products - chemistry
Chemical bonds
Chemical synthesis
Metals - chemistry
Natural products
Organic Chemicals - chemistry
Organic chemistry
Organic Chemistry Phenomena
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Zusammenfassung:An examination of the history of the complete chemical synthesis of arynes, an uncharged reactive intermediate derived from an aromatic system, is presented. Arynes rapidly activate an aromatic ring by forming multiple carbon-carbon bonds, and the synthesis of natural products are dependent upon nucleophilic additions that are associated with carbon-carbon interactions.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr200478h