The New Cassane-Type Diterpenes from Caesalpinia minax
Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin O (9), Neoc...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2012/06/01, Vol.60(6), pp.759-763 |
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| creator | Ma, Guo-Xu Yuan, Jing-Quan Cao, Li Yang, Jun-Shan Xu, Xu-Dong |
| description | Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin O (9), Neocaesalpin MP (10), and Magnicaesalpin (11). Their structures were elucidated on the basis of 1D- and 2D-NMR, MS, and circular dichroism (CD) analysis. Compounds 1-4 were tested against liver cancer (HepG-2) and breast cancer (MCF-7), and showed mild antiproliferative activity. |
| doi_str_mv | 10.1248/cpb.60.759 |
| format | Article |
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Their structures were elucidated on the basis of 1D- and 2D-NMR, MS, and circular dichroism (CD) analysis. Compounds 1-4 were tested against liver cancer (HepG-2) and breast cancer (MCF-7), and showed mild antiproliferative activity.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.60.759</identifier><identifier>PMID: 22689428</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; antiproliferative activity ; Breast Neoplasms - drug therapy ; Caesalpinia - chemistry ; Caesalpinia minax ; cassane-type diterpene ; Cell Proliferation - drug effects ; Circular Dichroism ; Diterpenes - chemistry ; Diterpenes - pharmacology ; Female ; Humans ; Inhibitory Concentration 50 ; Liver Neoplasms - drug therapy ; Magnetic Resonance Spectroscopy ; Molecular Structure</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2012/06/01, Vol.60(6), pp.759-763</ispartof><rights>2012 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c693t-3d58e43665c97cc84edff22651a4c34e742c18c2eb9e60d1102ddeef64995d793</citedby><cites>FETCH-LOGICAL-c693t-3d58e43665c97cc84edff22651a4c34e742c18c2eb9e60d1102ddeef64995d793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22689428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Guo-Xu</creatorcontrib><creatorcontrib>Yuan, Jing-Quan</creatorcontrib><creatorcontrib>Cao, Li</creatorcontrib><creatorcontrib>Yang, Jun-Shan</creatorcontrib><creatorcontrib>Xu, Xu-Dong</creatorcontrib><creatorcontrib>Ministry of Education</creatorcontrib><creatorcontrib>Institute of Medicinal Plant Development</creatorcontrib><creatorcontrib>Peking Union Medical College and Chinese Academy of Medical Sciences</creatorcontrib><creatorcontrib>Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine</creatorcontrib><creatorcontrib>Guangxi Botanical Garden of Medical Plant</creatorcontrib><title>The New Cassane-Type Diterpenes from Caesalpinia minax</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin O (9), Neocaesalpin MP (10), and Magnicaesalpin (11). Their structures were elucidated on the basis of 1D- and 2D-NMR, MS, and circular dichroism (CD) analysis. Compounds 1-4 were tested against liver cancer (HepG-2) and breast cancer (MCF-7), and showed mild antiproliferative activity.</description><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>antiproliferative activity</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Caesalpinia - chemistry</subject><subject>Caesalpinia minax</subject><subject>cassane-type diterpene</subject><subject>Cell Proliferation - drug effects</subject><subject>Circular Dichroism</subject><subject>Diterpenes - chemistry</subject><subject>Diterpenes - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Molecular Structure</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEuLFDEUhYMoTju68QdIgRsZqPbmXVlK64zCoJt2HdKpW3aaeplUM86_9449DxDCzeJ-OefkMPaWw5oL1XyM825tYG21e8ZWXCpbayHkc7YCAFcLaeQZe1XKAUBosPIlOxPCNE6JZsXMdo_Vd7ypNqGUMGK9vZ2x-pwWzDOOWKouTwMtsYR-TmMK1ZDG8Oc1e9GFvuCb-_uc_bz8st18ra9_XH3bfLquo3FyqWWrG1TSGB2djbFR2HYdmWseVJQKrRKRN1HgzqGBlnMQbYvYGeWcbq2T5-zDSXfO0-8jlsUPqUTse4o6HYunB8AdKG4Jff8fepiOeaR0nisDShtrDVEXJyrmqZSMnZ9zGkK-JSl_16anNr0BT20S_O5e8rgbsH1EH-oj4OoE0DbF0E9jn0Z8Mo7Fxj0OyVNK4QEMHQ_kBCRPwyhunFBck9LmpHQoS_iFj1YhLyn2-JDK3I34T4s-9bTdh-xxlH8BxB6biw</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Ma, Guo-Xu</creator><creator>Yuan, Jing-Quan</creator><creator>Cao, Li</creator><creator>Yang, Jun-Shan</creator><creator>Xu, Xu-Dong</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>The New Cassane-Type Diterpenes from Caesalpinia minax</title><author>Ma, Guo-Xu ; Yuan, Jing-Quan ; Cao, Li ; Yang, Jun-Shan ; Xu, Xu-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c693t-3d58e43665c97cc84edff22651a4c34e742c18c2eb9e60d1102ddeef64995d793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>antiproliferative activity</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Caesalpinia - chemistry</topic><topic>Caesalpinia minax</topic><topic>cassane-type diterpene</topic><topic>Cell Proliferation - drug effects</topic><topic>Circular Dichroism</topic><topic>Diterpenes - chemistry</topic><topic>Diterpenes - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Molecular Structure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Guo-Xu</creatorcontrib><creatorcontrib>Yuan, Jing-Quan</creatorcontrib><creatorcontrib>Cao, Li</creatorcontrib><creatorcontrib>Yang, Jun-Shan</creatorcontrib><creatorcontrib>Xu, Xu-Dong</creatorcontrib><creatorcontrib>Ministry of Education</creatorcontrib><creatorcontrib>Institute of Medicinal Plant Development</creatorcontrib><creatorcontrib>Peking Union Medical College and Chinese Academy of Medical Sciences</creatorcontrib><creatorcontrib>Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine</creatorcontrib><creatorcontrib>Guangxi Botanical Garden of Medical Plant</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Guo-Xu</au><au>Yuan, Jing-Quan</au><au>Cao, Li</au><au>Yang, Jun-Shan</au><au>Xu, Xu-Dong</au><aucorp>Ministry of Education</aucorp><aucorp>Institute of Medicinal Plant Development</aucorp><aucorp>Peking Union Medical College and Chinese Academy of Medical Sciences</aucorp><aucorp>Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine</aucorp><aucorp>Guangxi Botanical Garden of Medical Plant</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The New Cassane-Type Diterpenes from Caesalpinia minax</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2012</date><risdate>2012</risdate><volume>60</volume><issue>6</issue><spage>759</spage><epage>763</epage><pages>759-763</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin O (9), Neocaesalpin MP (10), and Magnicaesalpin (11). Their structures were elucidated on the basis of 1D- and 2D-NMR, MS, and circular dichroism (CD) analysis. Compounds 1-4 were tested against liver cancer (HepG-2) and breast cancer (MCF-7), and showed mild antiproliferative activity.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>22689428</pmid><doi>10.1248/cpb.60.759</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antiproliferative activity Breast Neoplasms - drug therapy Caesalpinia - chemistry Caesalpinia minax cassane-type diterpene Cell Proliferation - drug effects Circular Dichroism Diterpenes - chemistry Diterpenes - pharmacology Female Humans Inhibitory Concentration 50 Liver Neoplasms - drug therapy Magnetic Resonance Spectroscopy Molecular Structure |
| title | The New Cassane-Type Diterpenes from Caesalpinia minax |
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