The New Cassane-Type Diterpenes from Caesalpinia minax

Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin O (9), Neoc...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2012/06/01, Vol.60(6), pp.759-763
Hauptverfasser:	Ma, Guo-Xu, Yuan, Jing-Quan, Cao, Li, Yang, Jun-Shan, Xu, Xu-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antiproliferative activity Breast Neoplasms - drug therapy Caesalpinia - chemistry Caesalpinia minax cassane-type diterpene Cell Proliferation - drug effects Circular Dichroism Diterpenes - chemistry Diterpenes - pharmacology Female Humans Inhibitory Concentration 50 Liver Neoplasms - drug therapy Magnetic Resonance Spectroscopy Molecular Structure
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Zusammenfassung:	Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin O (9), Neocaesalpin MP (10), and Magnicaesalpin (11). Their structures were elucidated on the basis of 1D- and 2D-NMR, MS, and circular dichroism (CD) analysis. Compounds 1-4 were tested against liver cancer (HepG-2) and breast cancer (MCF-7), and showed mild antiproliferative activity.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.60.759