The Relationship between the Plasma Concentration of Bepridil and Its Efficacy in the Treatment of Atrial Fibrillation in Japanese Patients

The Relationship between the Plasma Concentration of Bepridil and Its Efficacy in the Treatment of Atrial Fibrillation in Japanese Patients

Bepridil hydrochloride is used for treatment of atrial fibrillation (AF) in Japan. We investigated the relationship between plasma concentrations of bepridil just before dosing (Cbep) and its clinical efficacy in Japanese patients (n=36) with AF. Patients were treated orally with 100, 150 or 200 mg/...

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Veröffentlicht in:Biological & pharmaceutical bulletin 2012/05/01, Vol.35(5), pp.672-676
Hauptverfasser: Noda, Kumiko, Gotoh, Yoshikazu, Tanioka, Satoru, Narayama, Yasuhiro, Kobayashi, Michiya, Iwai, Shinji, Katoh, Noriyoshi, Tadano, Koji
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adult
Aged
Aged, 80 and over
Anti-Arrhythmia Agents - blood
Anti-Arrhythmia Agents - therapeutic use
atrial fibrillation
Atrial Fibrillation - drug therapy
bepridil
Bepridil - blood
Bepridil - therapeutic use
bepridil plasma concentration
Female
Humans
Japan
Male
Middle Aged
QT prolongation
Treatment Outcome
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Zusammenfassung:Bepridil hydrochloride is used for treatment of atrial fibrillation (AF) in Japan. We investigated the relationship between plasma concentrations of bepridil just before dosing (Cbep) and its clinical efficacy in Japanese patients (n=36) with AF. Patients were treated orally with 100, 150 or 200 mg/d bepridil. Cbep were measured with UV-HPLC. In the first 14 d, when 150, 200, 250 or 300 ng/mL was set as a boundary value, the efficacy of bepridil was significantly higher in all patients with Cbep above than below the boundary value (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.35.672