Activation of alpha1-adrenoceptors enhances glutamate release onto ventral tegmental area dopamine cells

Highlights ► Presynaptic α1-ARs activation enhances glutamate release onto VTA DA neurons. ► This effect involves a selective activation of the PKC intracellular pathway. ► Presynaptic α1-AR-mediated effect requires extra- and intracellular calcium.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2012-08, Vol.216, p.18-30
Hauptverfasser:	Velásquez-Martinez, M.C, Vázquez-Torres, R, Jiménez-Rivera, C.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Adrenergic alpha-1 Receptor Agonists - pharmacology Adrenergic alpha-1 Receptor Antagonists - pharmacology alpha1-adrenoreceptors Animals Biological and medical sciences dopamine neurons Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Excitatory Postsynaptic Potentials - drug effects Fundamental and applied biological sciences. Psychology glutamate release Glutamic Acid - metabolism Male Neurology Neurons - drug effects Neurons - metabolism norepinephrine patch clamp Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha-1 - metabolism Receptors, AMPA - metabolism Receptors, Dopamine D1 - metabolism Signal Transduction - physiology Synaptic Transmission - drug effects ventral tegmental area Ventral Tegmental Area - drug effects Ventral Tegmental Area - metabolism Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Presynaptic α1-ARs activation enhances glutamate release onto VTA DA neurons. ► This effect involves a selective activation of the PKC intracellular pathway. ► Presynaptic α1-AR-mediated effect requires extra- and intracellular calcium.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.03.056