The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats

Background Sinusoidal obstruction syndrome (SOS) occurs in 50–70% of patients after oxaliplatin treatment for hepatic colorectal metastasis. SOS is associated with portal hypertension and is caused by oxidative damage to endothelial cells and matrix metalloproteinase (MMP) induction. We studied the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of surgical oncology 2012-07, Vol.106 (1), p.72-78
Hauptverfasser:	Ezzat, Tarek, van den Broek, Maartje A.J., Davies, Nathan, Dejong, Cornelis H.C., Bast, Aalt, Malagó, Massimo, Dhar, Dipok K., Olde Damink, Steven W.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Cell Line, Tumor Colorectal Neoplasms - drug therapy Endothelial Cells - drug effects Endothelial Cells - pathology Enzyme Induction - drug effects Gene Expression Regulation, Enzymologic Hepatic Veno-Occlusive Disease - chemically induced Hepatic Veno-Occlusive Disease - metabolism Hepatic Veno-Occlusive Disease - prevention & control Hydroxyethylrutoside - analogs & derivatives Hydroxyethylrutoside - pharmacology Liver - drug effects Liver - enzymology Liver - pathology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinases - biosynthesis Matrix Metalloproteinases - drug effects Matrix Metalloproteinases - metabolism Microscopy, Electron, Scanning Microscopy, Electron, Transmission Monocrotaline monoHER Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Oxidative Stress - drug effects Portal Pressure - drug effects prevention Protective Agents - pharmacology Rats Rats, Sprague-Dawley sinusoidal obstruction syndrome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background Sinusoidal obstruction syndrome (SOS) occurs in 50–70% of patients after oxaliplatin treatment for hepatic colorectal metastasis. SOS is associated with portal hypertension and is caused by oxidative damage to endothelial cells and matrix metalloproteinase (MMP) induction. We studied the effect of a flavonoid (monoHER) on SOS prevention. Methods A monocrotaline (MTC) SOS model was used in rats, with pre‐treatment of monoHER. We studied hepatocellular damage and MMP expression. The potential inhibition of oxaliplatin cytotoxicity by monoHER was tested in vitro in colorectal cancer cell lines. Results MonoHER ameliorated the increase in portal pressure after MCT (72 hr: 7.3 ± 2.7 mmHg vs. 11.4 ± 3.0 mmHg, P = 0.016 MCT + monoHER vs. MCT, P
ISSN:	0022-4790 1096-9098
DOI:	10.1002/jso.23046