Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases

Highlights ► We studied the effect of HIV-1 gp120 on different caspases (3, 6, 8, 9) expression. ► Gp120 was injected into the rat caudate-putamen. ► Caspases expression peaked by 24 h and they colocalized mainly with neurons. ► We then delivered antioxidant enzymes SOD1or GPx1 into the CP before in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2012-07, Vol.214, p.68-77
Hauptverfasser:	Louboutin, J.-P, Agrawal, L, Reyes, B.A.S, van Bockstaele, E.J, Strayer, D.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant enzymes Antioxidants - administration & dosage apoptosis Caspase Inhibitors - administration & dosage caspases Caspases - biosynthesis Caspases - metabolism Female Gene Expression Regulation, Enzymologic gene therapy Gene Transfer Techniques Glutathione Peroxidase - administration & dosage Glutathione Peroxidase - genetics gp120 HIV Envelope Protein gp120 - administration & dosage HIV Envelope Protein gp120 - antagonists & inhibitors HIV Envelope Protein gp120 - genetics human immunodeficiency virus type 1 Neurology Rats Rats, Sprague-Dawley Superoxide Dismutase - administration & dosage Superoxide Dismutase - genetics Superoxide Dismutase-1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► We studied the effect of HIV-1 gp120 on different caspases (3, 6, 8, 9) expression. ► Gp120 was injected into the rat caudate-putamen. ► Caspases expression peaked by 24 h and they colocalized mainly with neurons. ► We then delivered antioxidant enzymes SOD1or GPx1 into the CP before injecting gp120. ► Antioxidant enzymes delivery reduced production of caspases, by reducing ROS levels.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.03.061