Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats
An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting b...
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| Veröffentlicht in: | Phytotherapy research 2012-06, Vol.26 (6), p.944-948 |
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| container_title | Phytotherapy research |
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| creator | Huang, Mingqing Xie, Youliang Chen, Lidian Chu, Kedan Wu, Shuisheng Lu, Jinjian Chen, Xiuping Wang, Yitao Lai, Xiaoping |
| description | An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo. Copyright © 2011 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.3654 |
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The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo. Copyright © 2011 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.3654</identifier><identifier>PMID: 22095927</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Acids - chemistry ; Administration, Oral ; Animals ; Biological and medical sciences ; Blood Glucose - drug effects ; Blood Urea Nitrogen ; Danshen ; diabetes mellitus ; Diabetes Mellitus, Experimental - drug therapy ; Diet, High-Fat - adverse effects ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacology ; General pharmacology ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - pharmacology ; Insulin - blood ; Insulin Resistance ; Male ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenanthrolines - chemistry ; Phenanthrolines - pharmacology ; polyphenolic acids fraction ; Polyphenols - chemistry ; Polyphenols - pharmacology ; Rats ; Rats, Sprague-Dawley ; Salvia miltiorrhiza - chemistry ; Salvia miltiorrhiza Bunge ; Streptozocin - adverse effects</subject><ispartof>Phytotherapy research, 2012-06, Vol.26 (6), p.944-948</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4554-42e9fa2b7e0049ef7e2388e145357779dffb560b149fabf44a52fdc1f53cf5563</citedby><cites>FETCH-LOGICAL-c4554-42e9fa2b7e0049ef7e2388e145357779dffb560b149fabf44a52fdc1f53cf5563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.3654$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.3654$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25949149$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22095927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Mingqing</creatorcontrib><creatorcontrib>Xie, Youliang</creatorcontrib><creatorcontrib>Chen, Lidian</creatorcontrib><creatorcontrib>Chu, Kedan</creatorcontrib><creatorcontrib>Wu, Shuisheng</creatorcontrib><creatorcontrib>Lu, Jinjian</creatorcontrib><creatorcontrib>Chen, Xiuping</creatorcontrib><creatorcontrib>Wang, Yitao</creatorcontrib><creatorcontrib>Lai, Xiaoping</creatorcontrib><title>Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo. Copyright © 2011 John Wiley & Sons, Ltd.</description><subject>Acids - chemistry</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Urea Nitrogen</subject><subject>Danshen</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Drug Evaluation, Preclinical</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>General pharmacology</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenanthrolines - chemistry</subject><subject>Phenanthrolines - pharmacology</subject><subject>polyphenolic acids fraction</subject><subject>Polyphenols - chemistry</subject><subject>Polyphenols - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Salvia miltiorrhiza - chemistry</subject><subject>Salvia miltiorrhiza Bunge</subject><subject>Streptozocin - adverse effects</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EFvFCEYBmBiNHZbTfwFhouJl6nAwLAc17a7mqx1U9fUeCEMAy7KDCuwbbe_XppO25Mnko8n7_flBeANRscYIfJhm-Nx3TD6DEwwEqLCjNfPwQQJhiuKpz8OwGFKvxFCgiD6EhwQUr4E4RPgZ0N2nVOtyU7DM2uNzjBYmDcGrkNWHq6C3283Zgi-gJl2XYLzqHR2YYA2hh5-U_7KKdg7X2Yxbtytgh93wy8D3QBPH6IvVE6vwAurfDKvx_cIfJ-frU8-Vcuvi88ns2WlKWO0osQIq0jLDUJUGMsNqadTgymrGedcdNa2rEEtpoW1llLFiO00tqzWlrGmPgLv73O3MfzdmZRl75I23qvBhF2SGGHRYMYIe6I6hpSisXIbXa_iviB5160s3cq7bgt9O6bu2t50j_ChzALejUAlrbyNatAuPTkmqCg3F1fdu2vnzf6_C-VqfTEuHr1L2dw8ehX_yIbXnMnL84X8Of-yXJ2Shbys_wHnip-b</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Huang, Mingqing</creator><creator>Xie, Youliang</creator><creator>Chen, Lidian</creator><creator>Chu, Kedan</creator><creator>Wu, Shuisheng</creator><creator>Lu, Jinjian</creator><creator>Chen, Xiuping</creator><creator>Wang, Yitao</creator><creator>Lai, Xiaoping</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats</title><author>Huang, Mingqing ; Xie, Youliang ; Chen, Lidian ; Chu, Kedan ; Wu, Shuisheng ; Lu, Jinjian ; Chen, Xiuping ; Wang, Yitao ; Lai, Xiaoping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4554-42e9fa2b7e0049ef7e2388e145357779dffb560b149fabf44a52fdc1f53cf5563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acids - chemistry</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Urea Nitrogen</topic><topic>Danshen</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Drug Evaluation, Preclinical</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>General pharmacology</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. 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Drug treatments</topic><topic>Phenanthrolines - chemistry</topic><topic>Phenanthrolines - pharmacology</topic><topic>polyphenolic acids fraction</topic><topic>Polyphenols - chemistry</topic><topic>Polyphenols - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Salvia miltiorrhiza - chemistry</topic><topic>Salvia miltiorrhiza Bunge</topic><topic>Streptozocin - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Mingqing</creatorcontrib><creatorcontrib>Xie, Youliang</creatorcontrib><creatorcontrib>Chen, Lidian</creatorcontrib><creatorcontrib>Chu, Kedan</creatorcontrib><creatorcontrib>Wu, Shuisheng</creatorcontrib><creatorcontrib>Lu, Jinjian</creatorcontrib><creatorcontrib>Chen, Xiuping</creatorcontrib><creatorcontrib>Wang, Yitao</creatorcontrib><creatorcontrib>Lai, Xiaoping</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Mingqing</au><au>Xie, Youliang</au><au>Chen, Lidian</au><au>Chu, Kedan</au><au>Wu, Shuisheng</au><au>Lu, Jinjian</au><au>Chen, Xiuping</au><au>Wang, Yitao</au><au>Lai, Xiaoping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. 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| subjects | Acids - chemistry Administration, Oral Animals Biological and medical sciences Blood Glucose - drug effects Blood Urea Nitrogen Danshen diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diet, High-Fat - adverse effects Drug Evaluation, Preclinical Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology General pharmacology Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Insulin - blood Insulin Resistance Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenanthrolines - chemistry Phenanthrolines - pharmacology polyphenolic acids fraction Polyphenols - chemistry Polyphenols - pharmacology Rats Rats, Sprague-Dawley Salvia miltiorrhiza - chemistry Salvia miltiorrhiza Bunge Streptozocin - adverse effects |
| title | Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats |
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