Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats

An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting b...

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Veröffentlicht in:	Phytotherapy research 2012-06, Vol.26 (6), p.944-948
Hauptverfasser:	Huang, Mingqing, Xie, Youliang, Chen, Lidian, Chu, Kedan, Wu, Shuisheng, Lu, Jinjian, Chen, Xiuping, Wang, Yitao, Lai, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - chemistry Administration, Oral Animals Biological and medical sciences Blood Glucose - drug effects Blood Urea Nitrogen Danshen diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diet, High-Fat - adverse effects Drug Evaluation, Preclinical Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology General pharmacology Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Insulin - blood Insulin Resistance Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenanthrolines - chemistry Phenanthrolines - pharmacology polyphenolic acids fraction Polyphenols - chemistry Polyphenols - pharmacology Rats Rats, Sprague-Dawley Salvia miltiorrhiza - chemistry Salvia miltiorrhiza Bunge Streptozocin - adverse effects
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Zusammenfassung:	An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo. Copyright © 2011 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.3654