The system epilepsies: A pathophysiological hypothesis
Summary We postulate that “system epilepsies” (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis—that some types of epilepsy depend on the dysfunction of specific neural systems—are reviewed. The SystE hypothesi...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2012-05, Vol.53 (5), p.771-778 |
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| container_title | Epilepsia (Copenhagen) |
| container_volume | 53 |
| creator | Avanzini, Giuliano Manganotti, Paolo Meletti, Stefano Moshé, Solomon L. Panzica, Ferruccio Wolf, Peter Capovilla, Giuseppe |
| description | Summary
We postulate that “system epilepsies” (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis—that some types of epilepsy depend on the dysfunction of specific neural systems—are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives. |
| doi_str_mv | 10.1111/j.1528-1167.2012.03462.x |
| format | Article |
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We postulate that “system epilepsies” (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis—that some types of epilepsy depend on the dysfunction of specific neural systems—are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2012.03462.x</identifier><identifier>PMID: 22533642</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Brain ; Brain - physiopathology ; Cortico-cortical connections ; Data processing ; Epilepsy ; Epilepsy - classification ; Epilepsy - pathology ; Focal epilepsies ; Generalized epilepsies ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Hypotheses ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neural systems ; Neurology ; Neuropharmacology ; Pharmacology. Drug treatments ; Reviews ; Seizures ; Thalamo-cortical systems</subject><ispartof>Epilepsia (Copenhagen), 2012-05, Vol.53 (5), p.771-778</ispartof><rights>Wiley Periodicals, Inc. © 2012 International League Against Epilepsy</rights><rights>2015 INIST-CNRS</rights><rights>Wiley Periodicals, Inc. © 2012 International League Against Epilepsy.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6142-38215218d442ac56bc05faab6600e534a38846fb8167d0f45c47a73665355db83</citedby><cites>FETCH-LOGICAL-c6142-38215218d442ac56bc05faab6600e534a38846fb8167d0f45c47a73665355db83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2012.03462.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2012.03462.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25884167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22533642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avanzini, Giuliano</creatorcontrib><creatorcontrib>Manganotti, Paolo</creatorcontrib><creatorcontrib>Meletti, Stefano</creatorcontrib><creatorcontrib>Moshé, Solomon L.</creatorcontrib><creatorcontrib>Panzica, Ferruccio</creatorcontrib><creatorcontrib>Wolf, Peter</creatorcontrib><creatorcontrib>Capovilla, Giuseppe</creatorcontrib><title>The system epilepsies: A pathophysiological hypothesis</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
We postulate that “system epilepsies” (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis—that some types of epilepsy depend on the dysfunction of specific neural systems—are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.</description><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - physiopathology</subject><subject>Cortico-cortical connections</subject><subject>Data processing</subject><subject>Epilepsy</subject><subject>Epilepsy - classification</subject><subject>Epilepsy - pathology</subject><subject>Focal epilepsies</subject><subject>Generalized epilepsies</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neural systems</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Reviews</subject><subject>Seizures</subject><subject>Thalamo-cortical systems</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1P2zAYha1paBS2v4AiTZN2k-Bvm0lcIManYKCp0y4tJ3UWd2kT8rai-fe8oaVIXOELO5Kfc_zmHEISRjOG63CaMcVtypg2GaeMZ1RIzbPVBzLaXnwkI0qZSI-UpbtkD2BKKTXaiE9kl3MlhJZ8RPS4Cgn0sAizJLSxDi3EAD-Sk6T1i6ppqx5iUzf_YuHrpOrbZlEFiPCZ7JS-hvBlc-6TP-dn49PL9Obu4ur05CYtNJM8FZbjPMxOpOS-UDovqCq9z7WmNCghvbBW6jK3OO-EllIV0ngjtFZCqUluxT75vvZtu-ZhGWDhZhGKUNd-HpolOEaZtRo39R7UHGkqjEb06xt02iy7Of6IY4oZrqliEim7poquAehC6douznzXo5UbanBTN6TthrTdUIN7rsGtUHqweWCZz8JkK3zJHYFvG8ADJlt2fl5EeOUU5oKuyB2vuUespn_3AO7s_mr4Qn261kdseLXV--6_Q3ej3N9fF-6W_fx9PubXqH4C1dmugQ</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Avanzini, Giuliano</creator><creator>Manganotti, Paolo</creator><creator>Meletti, Stefano</creator><creator>Moshé, Solomon L.</creator><creator>Panzica, Ferruccio</creator><creator>Wolf, Peter</creator><creator>Capovilla, Giuseppe</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201205</creationdate><title>The system epilepsies: A pathophysiological hypothesis</title><author>Avanzini, Giuliano ; Manganotti, Paolo ; Meletti, Stefano ; Moshé, Solomon L. ; Panzica, Ferruccio ; Wolf, Peter ; Capovilla, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6142-38215218d442ac56bc05faab6600e534a38846fb8167d0f45c47a73665355db83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - physiopathology</topic><topic>Cortico-cortical connections</topic><topic>Data processing</topic><topic>Epilepsy</topic><topic>Epilepsy - classification</topic><topic>Epilepsy - pathology</topic><topic>Focal epilepsies</topic><topic>Generalized epilepsies</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neural systems</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Reviews</topic><topic>Seizures</topic><topic>Thalamo-cortical systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avanzini, Giuliano</creatorcontrib><creatorcontrib>Manganotti, Paolo</creatorcontrib><creatorcontrib>Meletti, Stefano</creatorcontrib><creatorcontrib>Moshé, Solomon L.</creatorcontrib><creatorcontrib>Panzica, Ferruccio</creatorcontrib><creatorcontrib>Wolf, Peter</creatorcontrib><creatorcontrib>Capovilla, Giuseppe</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avanzini, Giuliano</au><au>Manganotti, Paolo</au><au>Meletti, Stefano</au><au>Moshé, Solomon L.</au><au>Panzica, Ferruccio</au><au>Wolf, Peter</au><au>Capovilla, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The system epilepsies: A pathophysiological hypothesis</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2012-05</date><risdate>2012</risdate><volume>53</volume><issue>5</issue><spage>771</spage><epage>778</epage><pages>771-778</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
We postulate that “system epilepsies” (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis—that some types of epilepsy depend on the dysfunction of specific neural systems—are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22533642</pmid><doi>10.1111/j.1528-1167.2012.03462.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain Brain - physiopathology Cortico-cortical connections Data processing Epilepsy Epilepsy - classification Epilepsy - pathology Focal epilepsies Generalized epilepsies Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hypotheses Medical sciences Nervous system (semeiology, syndromes) Neural systems Neurology Neuropharmacology Pharmacology. Drug treatments Reviews Seizures Thalamo-cortical systems |
| title | The system epilepsies: A pathophysiological hypothesis |
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