The system epilepsies: A pathophysiological hypothesis

Summary We postulate that “system epilepsies” (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis—that some types of epilepsy depend on the dysfunction of specific neural systems—are reviewed. The SystE hypothesi...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2012-05, Vol.53 (5), p.771-778
Hauptverfasser:	Avanzini, Giuliano, Manganotti, Paolo, Meletti, Stefano, Moshé, Solomon L., Panzica, Ferruccio, Wolf, Peter, Capovilla, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain Brain - physiopathology Cortico-cortical connections Data processing Epilepsy Epilepsy - classification Epilepsy - pathology Focal epilepsies Generalized epilepsies Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hypotheses Medical sciences Nervous system (semeiology, syndromes) Neural systems Neurology Neuropharmacology Pharmacology. Drug treatments Reviews Seizures Thalamo-cortical systems
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Zusammenfassung:	Summary We postulate that “system epilepsies” (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis—that some types of epilepsy depend on the dysfunction of specific neural systems—are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.
ISSN:	0013-9580 1528-1167
DOI:	10.1111/j.1528-1167.2012.03462.x