Limiting inflammatory response to cardiopulmonary bypass: pharmaceutical strategies

Highlights ► Corticosteroids, statins and angiotensin converting enzyme inhibitors attenuate post-CPB inflammatory response. ► Statins reduce oxidative stress that may aid in maintaining long-term graft patency. ► Certain angiotensin converting enzyme inhibitors can be pro-fibrinolytic, with potenti...

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Veröffentlicht in:	Current opinion in pharmacology 2012-04, Vol.12 (2), p.155-159
Hauptverfasser:	Ng, Calvin SH, Wan, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - therapeutic use Angiotensin-Converting Enzyme Inhibitors - therapeutic use Anti-Inflammatory Agents - therapeutic use Antifibrinolytic Agents - therapeutic use Cardiopulmonary Bypass - adverse effects Coronary Artery Bypass - adverse effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Internal Medicine Medical Education Platelet Aggregation Inhibitors - therapeutic use Postoperative Complications - prevention & control
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Beschreibung
Zusammenfassung:	Highlights ► Corticosteroids, statins and angiotensin converting enzyme inhibitors attenuate post-CPB inflammatory response. ► Statins reduce oxidative stress that may aid in maintaining long-term graft patency. ► Certain angiotensin converting enzyme inhibitors can be pro-fibrinolytic, with potential implications in reducing the risk of acute graft thrombosis. ► Combined clopidogrel and aspirin therapy may improve short-term graft patency within the first few months after CABG.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2012.01.007