Serum procarboxypeptidase A and carboxypeptidase A levels in pancreatıc disease

Background and objectives: To determine the serum levels of procarboxypeptidase A (pro-CPA) and carboxypeptidase A (CPA) in patients with acute and chronic pancreatitis and pancreatic cancer. Materials and methods: Serum samples obtained from 96 patients with acute pancreatitis, 101 patients with ch...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human & experimental toxicology 2012-05, Vol.31 (5), p.447-451
Hauptverfasser:	Kemik, Ozgur, Kemik, Ahu Sarbay, Sumer, Aziz, Beğenik, Hüseyin, Dülger, Ahmet Cumhur, Purisa, Sevim, Tuzun, Sefa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biochemistry Biological and medical sciences biomarkers Carboxypeptidase A Carboxypeptidases A - blood Case-Control Studies Data processing Enzymes Female Gastroenterology. Liver. Pancreas. Abdomen Humans Inflammatory diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Pancreas Pancreatic cancer Pancreatic diseases Pancreatic Neoplasms - blood Pancreatic Neoplasms - epidemiology Pancreatitis Pancreatitis - blood Pancreatitis - epidemiology Serum levels Toxicology Tumors Young Adult
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background and objectives: To determine the serum levels of procarboxypeptidase A (pro-CPA) and carboxypeptidase A (CPA) in patients with acute and chronic pancreatitis and pancreatic cancer. Materials and methods: Serum samples obtained from 96 patients with acute pancreatitis, 101 patients with chronic pancreatitis, 98 patients with pancreatic cancer and 96 control groups were assayed for biochemical parameters and serum pro-CPA and CPA. Results: Serum pro-CPA and CPA levels were significantly higher in acute and in chronic pancreatic cancer patients compared to control group (p < 0.001). Pancreatic cancer patients had significantly higher serum pro-CPA and CPA levels when compared with acute and chronic pancreatitis cases (p < 0.001). Conclusion: These data prove for increased pro-CPA and CPA levels as a biomarker for the diagnosis of pancreatitis and pancreatic cancer.
ISSN:	0960-3271 1477-0903
DOI:	10.1177/0960327111405864