Neuroprotective effects of neuroglobin after mechanical injury

Neuroglobin (NGB) is a recently discovered globin, which is widely expressed in vertebrates central and peripheral nervous systems. Previous studies have shown that NGB is important in protecting neurons from hypoxic/ischemic brain injuries. However, there are no reports on the neuroprotective effec...

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Veröffentlicht in:	Neurological sciences 2012-06, Vol.33 (3), p.551-558
Hauptverfasser:	Shang, Aijia, Liu, Kaidong, Wang, Hangyan, Wang, Jing, Hang, Xingyi, Yang, Ying, Wang, Zhongfeng, Zhang, Chenggang, Zhou, Dingbiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Brain Injuries - complications Brain Injuries - metabolism Brain Injuries - pathology Brain injury Cell survival Cells, Cultured Cerebral Cortex - cytology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Gene Expression Regulation - physiology Globins - metabolism Hypoxia Ischemia L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism Medicine Medicine & Public Health Nerve Tissue Proteins - blood Nerve Tissue Proteins - metabolism neuroglobin Neurology Neurons Neurons - drug effects Neuroprotection Neuroprotective Agents - metabolism Neuroradiology Neurosciences Neurosurgery Original Article Peripheral nervous system Physical Stimulation - adverse effects Prognosis Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Psychiatry Rats Rats, Wistar Time Factors Transfection - methods Traumatic brain injury
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Beschreibung
Zusammenfassung:	Neuroglobin (NGB) is a recently discovered globin, which is widely expressed in vertebrates central and peripheral nervous systems. Previous studies have shown that NGB is important in protecting neurons from hypoxic/ischemic brain injuries. However, there are no reports on the neuroprotective effects of NGB after mechanical injury. Currently, we showed that the NGB expression level in neurons increased continuously from 2 h after injury, and reached a peak at 16 h ( p
ISSN:	1590-1874 1590-3478
DOI:	10.1007/s10072-011-0772-4