Genomic Comparison between a Virulent Type A1 Strain of Francisella tularensis and Its Attenuated O-Antigen Mutant

Genomic Comparison between a Virulent Type A1 Strain of Francisella tularensis and Its Attenuated O-Antigen Mutant

We report the complete genome sequences of TI0902, a highly virulent type A1 strain, and TIGB03, a related, attenuated chemical mutant strain. Compared to the wild type, the mutant strain had 45 point mutations and a 75.9-kb duplicated region that had not been previously observed in Francisella spec...

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Veröffentlicht in:Journal of Bacteriology 2012-05, Vol.194 (10), p.2775-2776
Hauptverfasser: Modise, Thero, Ryder, Cheryl, Mane, Shrinivasrao P, Bandara, Aloka B, Jensen, Roderick V, Inzana, Thomas J
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Bacteriology
Biological and medical sciences
Francisella tularensis
Francisella tularensis - classification
Francisella tularensis - genetics
Francisella tularensis - pathogenicity
Fundamental and applied biological sciences. Psychology
genome
Genome Announcements
Genome, Bacterial
Genomics
Gram-negative bacteria
Microbiology
Miscellaneous
Molecular Sequence Data
mutants
Mutation
nucleotide sequences
O Antigens - genetics
point mutation
Virulence
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Zusammenfassung:We report the complete genome sequences of TI0902, a highly virulent type A1 strain, and TIGB03, a related, attenuated chemical mutant strain. Compared to the wild type, the mutant strain had 45 point mutations and a 75.9-kb duplicated region that had not been previously observed in Francisella species.
ISSN:0021-9193
1098-5530
1067-8832
DOI:10.1128/JB.00152-12