Five Novel Locations of Neocentromeres in Human: 18q22.1, Xq27.1 similar to 27.2, Acro p13, Acro p12, and Heterochromatin of Unknown Origin
Since the first report in 1993, an ectopic centromere, i.e. neocentromere formation, has been reported in more than 100 small supernumerary marker chromosomes (sSMC), in 7 instances of centromere repositioning, and in about a dozen cases with more complex chromosomal rearrangements. Here we report 2...
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Veröffentlicht in: | Cytogenetic and genome research 2012-04, Vol.136 (3), p.163-166 |
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Zusammenfassung: | Since the first report in 1993, an ectopic centromere, i.e. neocentromere formation, has been reported in more than 100 small supernumerary marker chromosomes (sSMC), in 7 instances of centromere repositioning, and in about a dozen cases with more complex chromosomal rearrangements. Here we report 2 new cases with centromere repositioning and 3 neocentric sSMC consisting exclusively of heterochromatic material. Yet, no centromere formation was reported for the regions 18q22.1 and Xq27.1 similar to 27.2 as it was observed in the 2 cases with centromere repositioning here; in both cases, cytogenetically an inversion was suggested. Two of the 3 neocentric sSMC were derived from a short arm of an acrocentric chromosome. The remainder neocentric sSMC case was previously reported and was stainable only by material derived from itself. Copyright [copy 2012 S. Karger AG, Basel |
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ISSN: | 1424-8581 1424-859X |
DOI: | 10.1159/000336648 |