Extended gastritis cystica profunda associated with Epstein‐Barr virus‐positive dysplasia and carcinoma with lymphoid stroma

We report a case of gastritis cystica porfunda (GCP) associated with gastric carcinoma with lymphoid stroma (CLS). There was dysplastic change in the transitional area between GCP and CLS. Epstein‐Barr virus (EBV) in situ hybridization (ISH) revealed positive reaction at the dysplastic area as well as at the CLS area. Immunohistochemical staining disclosed that dysplastic epithelium was similar to GCP in CK 20, MUC5AC, and E‐cadherin expression, but similar to CLS in MUC6, CEA, p53, c‐erb‐B2, and EBV‐ISH expression. Results of the EBV‐ISH suggested that EBV infection may play a role in dysplastic change.