Prolonging the expression duration of ultrasound-mediated gene transfection using PEI nanoparticles

Ultrasound (US) irradiation has been found to facilitate the inward transport of genetic materials across cell membranes (sonoporation). However, its transfection efficiency is generally low, and the expression duration of transfected gene is short. Polyethylenimine (PEI), a cationic polymer, has be...

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Veröffentlicht in:	Journal of controlled release 2012-05, Vol.160 (1), p.64-71
Hauptverfasser:	Lee, Jyun-Lin, Lo, Chia-Wen, Ka, Shuk-Man, Chen, Ann, Chen, Wen-Shiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line cell membranes Cell Survival - genetics Cell Survival - radiation effects Cellular internalization cultured cells deoxyribonuclease I digestion DNA - administration & dosage DNA - genetics Drug Carriers - chemistry Drug Stability endocytosis Gene delivery Gene Expression General pharmacology genes humans Imines - chemistry Injections, Intramuscular irradiation luciferase Luciferases - genetics Male Medical sciences Mice Mice, Inbred BALB C muscles nanoparticles Nanoparticles - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phonophoresis - methods Plasmids Polyethylenes - chemistry Polyethylenimine polymers protective effect Rabbits Sonoporation Surface Properties Time Factors transfection Transfection - methods ultrasonics Ultrasound-mediated gene delivery
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