Oxygenated Lipids: A Mode to WiPE Out Inflammation?

Oxygenated Lipids: A Mode to WiPE Out Inflammation?

The immunologically silent clearance of apoptotic cells is crucial for maintaining self-tolerance. In this issue of Immunity, Uderhardt et al. (2012) reveal a mechanism by which lipid oxidation by tissue resident macrophages could inhibit the engulfment of apoptotic cells by inflammatory monocytes.

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Bibliographische Detailangaben
Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2012-05, Vol.36 (5), p.699-701
Hauptverfasser: Hochreiter-Hufford, Amelia E., Ravichandran, Kodi S.
Format: Artikel
Sprache:eng
Schlagworte:
Disease
Genotype & phenotype
Lipids
Lupus
Lymphocytes
Rodents
Studies
Target recognition
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Zusammenfassung:The immunologically silent clearance of apoptotic cells is crucial for maintaining self-tolerance. In this issue of Immunity, Uderhardt et al. (2012) reveal a mechanism by which lipid oxidation by tissue resident macrophages could inhibit the engulfment of apoptotic cells by inflammatory monocytes.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2012.05.006