Prevalence of BRCA mutations in an unselected population of triple‐negative breast cancer

Prevalence of BRCA mutations in an unselected population of triple‐negative breast cancer

BACKGROUND: This study assessed BRCA1 and BRCA2 mutation prevalence in an unselected cohort of patients with triple‐negative breast cancer (BC). METHODS: One hundred ninety‐nine patients were enrolled. Triple negativity was defined as

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Bibliographische Detailangaben
Veröffentlicht in:Cancer 2012-06, Vol.118 (11), p.2787-2795
Hauptverfasser: Hartman, Anne‐Renee, Kaldate, Rajesh R., Sailer, Lisa M., Painter, Lisa, Grier, Charles E., Endsley, Robbin R., Griffin, Marlena, Hamilton, Stephanie A., Frye, Cynthia A., Silberman, Mark A., Wenstrup, Richard J., Sandbach, John F.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
BRCA1 gene
BRCA2 gene
breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Cohort Studies
Female
Genes, BRCA1
Genes, BRCA2
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Mutation Rate
Neoplasms, Hormone-Dependent - genetics
prevalence
Tumors
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Zusammenfassung:BACKGROUND: This study assessed BRCA1 and BRCA2 mutation prevalence in an unselected cohort of patients with triple‐negative breast cancer (BC). METHODS: One hundred ninety‐nine patients were enrolled. Triple negativity was defined as
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.26576