Mesenchymal stem cell therapy in acute lung injury: is it time for a clinical trial?

[...]the antimicrobial effect of MSC therapy requires further thought. [...]in addition to their potential use during ALI, MSCs or their products could have a role in reconditioning lungs harvested for transplantation, but subsequently deemed too severely injured for use.

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Bibliographische Detailangaben
Veröffentlicht in:	Thorax 2012-06, Vol.67 (6), p.475-476
Hauptverfasser:	Mac Sweeney, Rob, McAuley, Daniel Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lung injury Acute-Phase Proteins - metabolism Animals Clinical trials E coli Escherichia coli - pathogenicity Escherichia coli Infections - complications Escherichia coli Infections - surgery Growth factors Heart attacks Interleukin-10 - biosynthesis keratinocyte growth factor Lipocalin-2 Lipocalins - metabolism Lungs Male Mesenchymal stem cell Mesenchymal Stem Cell Transplantation Oncogene Proteins - metabolism Pneumonia Pneumonia, Bacterial - microbiology Stem cells Studies Tumor Necrosis Factor-alpha - drug effects Ventilator-Induced Lung Injury - surgery
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Beschreibung
Zusammenfassung:	[...]the antimicrobial effect of MSC therapy requires further thought. [...]in addition to their potential use during ALI, MSCs or their products could have a role in reconditioning lungs harvested for transplantation, but subsequently deemed too severely injured for use.
ISSN:	0040-6376 1468-3296
DOI:	10.1136/thoraxjnl-2011-201309