Needs for an Expanded Ontology-Based Classification of Adverse Drug Reactions and Related Mechanisms

Needs for an Expanded Ontology-Based Classification of Adverse Drug Reactions and Related Mechanisms

The growing significance of bioinformatics and systems biology in drug safety research requires a system of adverse‐event classification that goes beyond a simple vocabulary. This opinion piece outlines the need for development of an ontology‐based framework of describing adverse drug reactions (ADR...

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Veröffentlicht in:Clinical pharmacology and therapeutics 2012-06, Vol.91 (6), p.963-965
Hauptverfasser: Zhichkin, P E, Athey, B D, Avigan, M I, Abernethy, D R
Format: Artikel
Sprache:eng
Schlagworte:
Bayes Theorem
Classification
Clinical Trials as Topic
Computational Biology
Databases, Factual
Drug-Related Side Effects and Adverse Reactions - classification
Humans
Models, Organizational
Pharmacovigilance
Public Health
Terminology as Topic
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Zusammenfassung:The growing significance of bioinformatics and systems biology in drug safety research requires a system of adverse‐event classification that goes beyond a simple vocabulary. This opinion piece outlines the need for development of an ontology‐based framework of describing adverse drug reactions (ADRs) and describes the potential applications for such a framework. Clinical Pharmacology & Therapeutics (2012); 91 6, 963–965. doi:10.1038/clpt.2012.41
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2012.41