Growth hormone treatment impact on growth rate and final height of patients who received HSCT with TBI or and cranial irradiation in childhood: a report from the French Leukaemia Long-Term Follow-Up Study (LEA)

The literature contains a substantial amount of information about factors that adversely influence the linear growth in up to 85% of patients undergoing haematopoietic SCT (HSCT) with TBI and/or cranial irradiation (CI) for acute leukaemia (AL). By contrast, only a few studies have evaluated the impact of growth hormone (GH) therapy on growth rate and final height (FH) in these children. We evaluated growth rates during the pre- and post-transplant periods to FH in a group of 25 children treated with HSCT ( n =22), TBI ( n =21) or/and CI ( n =8) for AL and receiving GH therapy. At the start of GH treatment, the median height Z -score was −2.19 (−3.95 to 0.02), significantly lower than at AL diagnosis ( P