Landscape of TET2 mutations in acute myeloid leukemia

We investigated ten–eleven translocation 2 ( TET2) mutations in acute myeloid leukemia (AML), their correlation with other gene mutations and prognostic value. By deep-sequencing, 131 somatic TET2 mutations were identified in 87/318 (27.4%) patients. Of 87 mutated cases, 44 (50.6%) carried two mutat...

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Veröffentlicht in:	Leukemia 2012-05, Vol.26 (5), p.934-942
Hauptverfasser:	Weissmann, S, Alpermann, T, Grossmann, V, Kowarsch, A, Nadarajah, N, Eder, C, Dicker, F, Fasan, A, Haferlach, C, Haferlach, T, Kern, W, Schnittger, S, Kohlmann, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers Cancer Research Chromosome Banding Critical Care Medicine DNA Methylation DNA-Binding Proteins - genetics Female Gene mutations Health aspects Hematologic and hematopoietic diseases Hematology Humans In Situ Hybridization, Fluorescence Intensive Internal Medicine Janus kinase 2 Karyotypes Karyotyping Leukemia Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes Male Medical prognosis Medical sciences Medicine Medicine & Public Health Mutation Mutation, Missense Oncology original-article Patients Promoter Regions, Genetic Proto-Oncogene Proteins - genetics Risk groups Runx1 protein Subgroups Survival Survival Analysis Translocation Young Adult
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