Landscape of TET2 mutations in acute myeloid leukemia

We investigated ten–eleven translocation 2 ( TET2) mutations in acute myeloid leukemia (AML), their correlation with other gene mutations and prognostic value. By deep-sequencing, 131 somatic TET2 mutations were identified in 87/318 (27.4%) patients. Of 87 mutated cases, 44 (50.6%) carried two mutations. TET2 mutations were concomitantly observed with mutations in NPM1 , FLT3 -ITD, FLT3 -TKD, JAK2 , RUNX1 , CEBPA , CBL and KRAS. However, TET2 mutations rarely concomitantly occurred with IDH1 mut or IDH2 mut (2/251 or 0/184; P =0.046 and P =0.003, respectively). TET2 mutations were associated with normal karyotype AML (CN-AML) (62/206 (30.1%) CN-AML vs 20/107 (18.7%) aberrant karyotype; P =0.031), higher white blood cell count (mean 65.3 vs 40.3 × 10 9 /l, P =0.023), lower platelet count (mean 68.6 vs 92.4 × 10 9 /l, P =0.03) and higher age (67.5 vs 65.2 years, P