A comprehensive cytogenetic classification of 1466 Chinese patients with de novo acute lymphoblastic leukemia

Abstract Cytogenetics and molecular cytogenetics of 1466 Chinese patients with d e novo acute lymphoblastic leukemia (ALL) were studied. Cytogenetic results were available in 1175 patients. Cross-correlations of 23 subclasses of cytogenetic abnormalities were described. Childhood cases had higher incidences of normal karyotype, t(1;19), +8, 12q−, +21, +22 and high hyperdiploidy with 51–65 chromosomes, and lower incidences of t(9;22) and −5/5q− than adult ones (all p < 0.05). Relationships of cytogenetic subclasses with immunophenotyping subgroups of ALL were studied. Our study presents the cytogenetic characteristics of a large series of Chinese ALL patients.