Stability of Extemporaneously Prepared 0.5-Percent Caspofungin Eye Drops: a Potential Cost-Savings Exercise

While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were me...

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2012-06, Vol.56 (6), p.3435-3437
Hauptverfasser:	Neoh, Chin Fen, Jacob, Jovan, Leung, Lok, Li, Jian, Stathopoulos, Angela, Stewart, Kay, Kong, David C. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents antifungal agents Biological and medical sciences Chromatography, High Pressure Liquid Clinical Therapeutics cost effectiveness Drug Stability Drug Storage Drug Storage - economics Drug Storage - methods Echinocandins economics eyes fungi high performance liquid chromatography keratitis Lipopeptides Medical sciences methods Ophthalmic Solutions patients Pharmacology. Drug treatments topical application
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Zusammenfassung:	While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis. The preparations remained stable for 28 days under refrigerated condition but not at 25.0°C. Our study supports the cost-saving use of caspofungin eye drops in the clinical setting.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00060-12