The effect of body mass index on spinal anaesthesia for total knee replacement arthroplasty: a dose-response study

The aim of this study was to compare the duration of spinal anaesthesia in obese and non-obese subjects. We also quantified the effect of body mass index (BMI) on spinal anaesthesia by comparing the median effective dose (ED50) of intrathecal hyperbaric bupivacaine required in the two cohorts. One h...

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Veröffentlicht in:	Anaesthesia and intensive care 2012-05, Vol.40 (3), p.410-416
Hauptverfasser:	KIM, W. H, LEE, J. H, KO, J. S, AHN, H. J, PARK, S. K, GWAK, M. S, KIM, G. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia Anesthesia, Spinal - adverse effects Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Local - administration & dosage Arthroplasty, Replacement, Knee Biological and medical sciences Body Mass Index Bupivacaine - administration & dosage Dose-response relationship (Biochemistry) Dose-Response Relationship, Drug Double-Blind Method Female Health aspects Humans Hypotension - physiopathology Logistic Models Lower Extremity Male Medical sciences Middle Aged Monitoring, Physiologic Obesity Obesity - complications Patient outcomes Prospective Studies Regional anesthesia Regression Analysis Tourniquets
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Zusammenfassung:	The aim of this study was to compare the duration of spinal anaesthesia in obese and non-obese subjects. We also quantified the effect of body mass index (BMI) on spinal anaesthesia by comparing the median effective dose (ED50) of intrathecal hyperbaric bupivacaine required in the two cohorts. One hundred and eight patients undergoing elective total knee replacement arthroplasty under combined spinal-epidural anaesthesia were enrolled as a non-obese group (BMI
ISSN:	0310-057X 1448-0271
DOI:	10.1177/0310057X1204000305