Renal iron load in sickle cell disease is influenced by severity of haemolysis

Summary Spin density projection‐assisted R2‐magnetic resonance imaging (R2‐MRI; FerriScan®) scans from 40 chelation‐naïve sickle cell patients were used to assess renal iron load by measuring renal R2 (R‐R2). Clinical data were collected retrospectively for the 2‐year period preceding the scan. R‐R2...

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Veröffentlicht in:	British journal of haematology 2012-06, Vol.157 (5), p.599-605
Hauptverfasser:	Vasavda, Nisha, Gutiérrez, Lucía, House, Michael J., Drašar, Emma, St Pierre, Tim G., Thein, Swee L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anemia, Sickle Cell - complications Anemia, Sickle Cell - therapy Anemias. Hemoglobinopathies Biological and medical sciences Diseases of red blood cells Female haemolysis Hematologic and hematopoietic diseases Hemolysis Humans imaging Iron - metabolism Iron Overload - diagnosis Iron Overload - etiology Kidney - metabolism Kidney - pathology Kidney - physiopathology Magnetic Resonance Imaging Male Medical sciences Middle Aged renal iron sickle cell Transfusion Reaction Young Adult
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Zusammenfassung:	Summary Spin density projection‐assisted R2‐magnetic resonance imaging (R2‐MRI; FerriScan®) scans from 40 chelation‐naïve sickle cell patients were used to assess renal iron load by measuring renal R2 (R‐R2). Clinical data were collected retrospectively for the 2‐year period preceding the scan. R‐R2 showed no significant correlation with transfusional iron load (assessed by liver iron concentration), but correlated significantly with serum bilirubin (R = 0·61, P
ISSN:	0007-1048 1365-2141
DOI:	10.1111/j.1365-2141.2012.09093.x