Synthesis, characterization and evaluation of mannich bases as potent antifungal and hydrogen peroxide scavenging agents

In the present study, (E)-2-{ [-2-(2,4-Dinitrophenyl)hydrazono]methyl} phenol (3) was synthesized and used as key intermediate for the synthesis of new Mannich bases. All the synthesized compounds were evaluated for their antifungal activity against three fungal strains Candida albicans, Candida tro...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2012-03, Vol.69 (2), p.355-361
Hauptverfasser:	Malhotra, Manav, Sharma, Rajiv, Sanduja, Mohit, Kumar, Rajeev, Jain, Jainendra, Deep, Aakash
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Hydrogen Peroxide - metabolism Magnetic Resonance Spectroscopy Mannich Bases - chemical synthesis Mannich Bases - pharmacology
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Zusammenfassung:	In the present study, (E)-2-{ [-2-(2,4-Dinitrophenyl)hydrazono]methyl} phenol (3) was synthesized and used as key intermediate for the synthesis of new Mannich bases. All the synthesized compounds were evaluated for their antifungal activity against three fungal strains Candida albicans, Candida tropicalis and Aspergillus niger and antioxidant activity. The structure of these compounds was confirmed by IR, 1H NMR and 13C NMR studies. Most of the compounds exhibited moderate to significant activities.
ISSN:	0001-6837