Endocrine archeology: Do insects retain ancestrally inherited counterparts of the vertebrate releasing hormones GnRH, GHRH, TRH, and CRF?

Endocrine archeology: Do insects retain ancestrally inherited counterparts of the vertebrate releasing hormones GnRH, GHRH, TRH, and CRF?

Graphical abstract Highlights ► A nematodes peptide activates both the GnRH and the insect adipokinetic hormone (AKH) receptor. ► The very ancient ancestor of growth hormone releasing hormone (GHRH) may have been glucagon-like. ► A challenging hypothesis: juvenile hormone developed as ersatz for thy...

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Veröffentlicht in:General and comparative endocrinology 2012-05, Vol.177 (1), p.18-27
Hauptverfasser: Loof, Arnold De, Lindemans, Marleen, Liu, Feng, De Groef, Bert, Schoofs, Liliane
Format: Artikel
Sprache:eng
Schlagworte:
adipokinetic hormone
AKH
Animals
Annelida
Archaeology - methods
arthropods
bioinformatics
corticotropin
Corticotropin-Releasing Hormone - metabolism
diuretic hormone
Endocrinology & Metabolism
energy metabolism
genes
GnRH
Gonadotropin
gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone - metabolism
Growth Hormone-Releasing Hormone - metabolism
hypothalamus
Insect hormones
Insecta
juvenile hormones
Juvenile Hormones - metabolism
locusts
Models, Biological
molluscs
Nematoda
Neuropeptides
phylogeny
Releasing hormone
somatoliberin
thyroid hormones
thyrotropin-releasing hormone
Thyrotropin-Releasing Hormone - metabolism
vertebrates
water metabolism
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Beschreibung
Zusammenfassung:Graphical abstract Highlights ► A nematodes peptide activates both the GnRH and the insect adipokinetic hormone (AKH) receptor. ► The very ancient ancestor of growth hormone releasing hormone (GHRH) may have been glucagon-like. ► A challenging hypothesis: juvenile hormone developed as ersatz for thyroid hormone signaling. ► CRF is well conserved in insects and functions as an antidiuretic hormone. ► The ancestral releasing hormone precursors may have controlled energy and water metabolism.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2012.02.002