Coumarin-based chiral fluorescence sensor incorporating a thiourea unit for highly enantioselective recognition of N-Boc-protected proline

Coumarin-based chiral fluorescence sensor incorporating a thiourea unit for highly enantioselective recognition of N-Boc-protected proline

New coumarin-based chiral thiourea sensor 1 was found to be an enantioselective fluorescent chemosensor for N-Boc-protected proline. The chiral sensor shows lower background fluorescence, and higher fluorescence enhancement with 18 nm blue shifts. Job plot analysis result indicates that sensor 1 can...

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Veröffentlicht in:Organic & biomolecular chemistry 2012-05, Vol.10 (20), p.4024-4028
Hauptverfasser: Xing, Zhitao, Fu, Yong, Zhou, Jiecong, Zhu, Chengjian, Cheng, Yixiang
Format: Artikel
Sprache:eng
Schlagworte:
Coumarins - chemistry
Fluorescent Dyes - chemistry
Molecular Structure
Proline - analysis
Proline - chemistry
Stereoisomerism
Thiourea - chemistry
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Zusammenfassung:New coumarin-based chiral thiourea sensor 1 was found to be an enantioselective fluorescent chemosensor for N-Boc-protected proline. The chiral sensor shows lower background fluorescence, and higher fluorescence enhancement with 18 nm blue shifts. Job plot analysis result indicates that sensor 1 can form a 1 : 1 stoichiometric complex and it could be used as a fluorescence sensor for the determination of enantiomer composition of N-Boc-protected proline.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob25311a