Biochemical control of prostate cancer with iodine-125 brachytherapy alone: experience from a single institution

Aim Brachytherapy is an adequate option as monotherapy for localised prostate cancer. The objective of this study was to evaluate and compare biochemical failure free survival (BFFS) after low-dose-rate brachytherapy (LDRB) alone for patients with prostate cancer using ASTRO and Phoenix criteria, and detect prognostic factors. Methods Data on 220 patients treated between 1998 and 2002 with LDRB were retrospectively analysed. Neoadjuvant hormone therapy was used in 74 (33.6%) patients. Results Median follow-up was 53.5 months (24–116). Five year BFFS was 83.0% and 83.7% using, respectively, the ASTRO and Phoenix criteria. Low -and intermediate-risk patients presented, respectively, 86.7% and 77.8% 5-year BFFS using the ASTRO definition ( p =0.069), and 88.5% and 78.6% considering the Phoenix criteria ( p =0.016). Bounce was observed in 66 (30%) patients. Multivariate analysis detected PSA at diagnosis