Potential role of AQP1 and VEGF in the development of malignant pleural effusion in mice

Recent studies have revealed the important role of aquaporin-1 (AQP1) in tumor cell migration and angiogenesis. However, the function of AQP1 in malignant pleural effusion has not been well characterized. We established a mouse model to examine the role of AQP1 and vascular endothelial growth factor...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2012-06, Vol.29 (2), p.656-662
Hauptverfasser:	Zhang, Jing Xuan, Xie, C. M., Zhu, Z. W., Huang, H. Y., Zeng, Z. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 1 - genetics Aquaporin 1 - metabolism Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Lewis Lung - genetics Carcinoma, Lewis Lung - metabolism Carcinoma, Lewis Lung - pathology Hematology Immunoenzyme Techniques Internal Medicine Medicine Medicine & Public Health Mice Mice, Inbred C57BL Oncology Original Paper Pathology Pleural Effusion, Malignant - genetics Pleural Effusion, Malignant - metabolism Pleural Effusion, Malignant - pathology Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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Zusammenfassung:	Recent studies have revealed the important role of aquaporin-1 (AQP1) in tumor cell migration and angiogenesis. However, the function of AQP1 in malignant pleural effusion has not been well characterized. We established a mouse model to examine the role of AQP1 and vascular endothelial growth factor (VEGF) in the development of malignant pleural effusion. We showed that elevated expressions of AQP1 mRNA and VEGF protein were associated with increased volume of malignant pleural effusion. These results suggest that AQP1 and VEGF play important roles in the development of malignant pleural effusion in mice, which may help us find new strategies for the prevention and treatment of malignant pleural effusion.
ISSN:	1357-0560 1559-131X
DOI:	10.1007/s12032-011-9960-6