The characteristics of remnant lipoproteins in the fasting and postprandial plasma

Remnant-like lipoprotein particles (RLP) have been measured by cholesterol as RLP-C for CHD risk assessment in the fasting plasma. However, RLP-triglyceride (TG) is a better marker of the characteristics of remnant lipoproteins in the postprandial plasma, especially in plasma with TG concentrations...

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Veröffentlicht in:Clinica chimica acta 2012-07, Vol.413 (13-14), p.1077-1086
Hauptverfasser: Nakajima, Katsuyuki, Nakano, Takamitsu, Tokita, Yoshiharu, Nagamine, Takeaki, Yatsuzuka, Shin-ichi, Shimomura, Younosuke, Tanaka, Akira, Sumino, Hiroyuki, Nara, Makoto, Machida, Tetsuo, Murakami, Masami
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Sprache:eng
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Zusammenfassung:Remnant-like lipoprotein particles (RLP) have been measured by cholesterol as RLP-C for CHD risk assessment in the fasting plasma. However, RLP-triglyceride (TG) is a better marker of the characteristics of remnant lipoproteins in the postprandial plasma, especially in plasma with TG concentrations 80mg/dl. RLP apoB100, but not RLP apoB48, increased significantly when the plasma TG increased after an oral fat load despite the increase of plasma apoB48. The results show that the major lipoproteins which were increased in postprandial plasma were VLDL remnants, not CM remnants. ► RLPs in fasting and postprandial plasma were determined. ► The changes of RLP in postprandial plasma were started at a TG level 80mg/dL. ► ApoB100, but not apoB48 in RLP was the major lipoproteins increased in postprandial plasma.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2012.02.026