Quantitative proteomics and metabolomics approaches to demonstrate N-acetyl-d-glucosamine inducible amino acid deprivation response as morphological switch in Candida albicans

► We studied GlcNAc induced morphogenesis in C. albicans by 2-DE and metabolomics approaches. ► Intracellular amino acid pool goes down and amino acid biosynthesis proteins are upregulated. ► GCN4 and GCN2 genes involved in GCN response are activated in presence of GlcNAc. ► Inactivation of these ge...

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Veröffentlicht in:Fungal genetics and biology 2012-05, Vol.49 (5), p.369-378
Hauptverfasser: Kamthan, Mohan, Mukhopadhyay, Gauranga, Chakraborty, Niranjan, Chakraborty, Subhra, Datta, Asis
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Sprache:eng
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