Uterine Smooth Muscle Tumors of Uncertain Malignant Potential: Diagnostic Challenges and Therapeutic Dilemmas. Report of 2 Cases and Review of the Literature

Abstract Morphologically, there exist variants of uterine smooth muscle tumors that cannot be clearly interpreted and classified as benign or malignant. Because their behavior and clinical prognosis is also uncertain, the World Health Organization has termed these “smooth muscle tumors of uncertain...

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Veröffentlicht in:	Journal of minimally invasive gynecology 2012-05, Vol.19 (3), p.288-295
Hauptverfasser:	Vilos, George A., MD, Marks, Jennifer, MD, Ettler, Helen C., MB, ChB, Vilos, Angelos G., MD, Prefontaine, Michel, MD, Abu-Rafea, Basim, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Diagnosis, Differential Epithelioid leiomyoma Female Fibroid Humans Leiomyoma Leiomyomatosis - diagnosis Leiomyomatosis - pathology Leiomyomatosis - therapy Leiomyosarcoma Leiomyosarcoma - diagnosis Leiomyosarcoma - pathology Leiomyosarcoma - therapy Muscle Neoplasms - diagnosis Muscle Neoplasms - pathology Muscle Neoplasms - therapy Obstetrics and Gynecology Prognosis Smooth Muscle Tumor - diagnosis Smooth Muscle Tumor - pathology Smooth Muscle Tumor - therapy Smooth muscle tumors of uncertain malignant potential STUMP Surgery Uterine Neoplasms - diagnosis Uterine Neoplasms - pathology Uterine Neoplasms - therapy Uterine tumors
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Zusammenfassung:	Abstract Morphologically, there exist variants of uterine smooth muscle tumors that cannot be clearly interpreted and classified as benign or malignant. Because their behavior and clinical prognosis is also uncertain, the World Health Organization has termed these “smooth muscle tumors of uncertain malignant potential” (STUMP). Herein we describe 2 cases, present a review of the literature, and highlight the diagnostic challenges and therapeutic dilemmas associated with uterine STUMP in myomectomy specimens from women who wish to maintain or enhance their fertility. The clinical course of residual STUMP remains speculative.
ISSN:	1553-4650 1553-4669
DOI:	10.1016/j.jmig.2011.12.025