Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice

Highlights ► An original and innovative research on Th2-biased immune response and pathogenic mechanisms of schistosomiasis is present. ► Areas in immunology that may benefit from immune-regulatory effects induced by the helminth–schistosome are also discussed.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2012-05, Vol.144 (1), p.60-66
Hauptverfasser:	Qi, Yao, Song, Xiao-rong, Shen, Ji-long, Xu, Yuan-hong, Shen, Qian, Luo, Qing-li, Zhong, Zheng-rong, Wang, Wei, Chu, De-yong, Song, Wen-jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Apoptosis Cell Differentiation Female Galectin-9 Galectins - genetics Galectins - metabolism Hepatitis A Virus Cellular Receptor 2 Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred BALB C Receptors, Virus - genetics Receptors, Virus - metabolism Schistosoma japonicum - immunology Schistosoma japonicum - pathogenicity Schistosomiasis Schistosomiasis japonica - immunology Schistosomiasis japonica - parasitology Schistosomiasis japonica - physiopathology T cell immunoglobulin domain and mucin domain T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - physiology Th2 Cells - immunology Th2 Cells - metabolism Th2-biased response Up-Regulation
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Beschreibung
Zusammenfassung:	Highlights ► An original and innovative research on Th2-biased immune response and pathogenic mechanisms of schistosomiasis is present. ► Areas in immunology that may benefit from immune-regulatory effects induced by the helminth–schistosome are also discussed.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2012.03.007