Lack of association between connexin40 polymorphisms and coronary artery disease
Highlights ► Human Cx40 is expressed under its promoter A in endothelial cells. ► Cx40 promoter A polymorphisms are not associated with coronary artery disease. ► Reduction of Cx40 expression by half may not be sufficient to promote atherosclerosis.
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| Veröffentlicht in: | Atherosclerosis 2012-05, Vol.222 (1), p.148-153 |
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| container_start_page | 148 |
| container_title | Atherosclerosis |
| container_volume | 222 |
| creator | Pfenniger, Anna van der Laan, Sander W Foglia, Bernard Dunoyer-Geindre, Sylvie Haefliger, Jacques-Antoine Winnik, Stephan Mach, François Pasterkamp, Gerard James, Richard W Kwak, Brenda R |
| description | Highlights ► Human Cx40 is expressed under its promoter A in endothelial cells. ► Cx40 promoter A polymorphisms are not associated with coronary artery disease. ► Reduction of Cx40 expression by half may not be sufficient to promote atherosclerosis. |
| doi_str_mv | 10.1016/j.atherosclerosis.2012.01.050 |
| format | Article |
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Vascular system</subject><subject>Cardiovascular</subject><subject>cell communication</subject><subject>Connexin40</subject><subject>Connexins - genetics</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary heart disease</subject><subject>endothelium</subject><subject>Female</subject><subject>Gap junction</subject><subject>Gap Junction alpha-5 Protein</subject><subject>Gene polymorphism</subject><subject>genes</subject><subject>genotype</subject><subject>Heart</subject><subject>hospitals</subject><subject>Human Umbilical Vein Endothelial Cells</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>mice</subject><subject>Middle Aged</subject><subject>patients</subject><subject>Plaque stability</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Polymorphism, Genetic</subject><subject>promoter regions</subject><subject>Promoter Regions, Genetic</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhi0EokvhL0Aulbgk-CuJfQCpqqAgrQRS6dly7An1NmsvdhbYf89Eu_TQExePZT8z8-qdIeSC0YZR1r3bNHa-g5yKm5YzlIZTxhvKGtrSJ2TFVK9rJpV8SlaUclZr1tIz8qKUDaVU9kw9J2ecS9pKyVbk29q6-yqNlS0luWDnkGI1wPwbIFYuxQh_QpS02qXpsE15dxfKtlQ2evzMKdp8qGyeAYMPBWyBl-TZaKcCr07xnNx--vj96nO9_nr95epyXTup1Vxrrd2glRSi59x2A2-1k86JtvVA-24cBjdw0Xqv2KA0PnZejOMoPd6HHpw4J2-PdXc5_dxDmc02FAfTZCOkfTGMUs24Ul2P6Psj6tCwkmE0uxy2KB0hs5hqNuaRqWYx1VBm0FTMf31qtR-24B-y_7mIwMUJsMXZacw2OqzxwLWKU6EW7s2RG20y9kdG5vYGO7XLZFQnNBLXRwLQul8BsikuQHTgQwY3G5_Cf4v-8KiSm0IMKO8eDlA2aZ8jzscwUzDH3Cy7sqwK4yhGCSn-Ajlivmg</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Pfenniger, Anna</creator><creator>van der Laan, Sander W</creator><creator>Foglia, Bernard</creator><creator>Dunoyer-Geindre, Sylvie</creator><creator>Haefliger, Jacques-Antoine</creator><creator>Winnik, Stephan</creator><creator>Mach, François</creator><creator>Pasterkamp, Gerard</creator><creator>James, Richard W</creator><creator>Kwak, Brenda R</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Lack of association between connexin40 polymorphisms and coronary artery disease</title><author>Pfenniger, Anna ; van der Laan, Sander W ; Foglia, Bernard ; Dunoyer-Geindre, Sylvie ; Haefliger, Jacques-Antoine ; Winnik, Stephan ; Mach, François ; Pasterkamp, Gerard ; James, Richard W ; Kwak, Brenda R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-999cb98433722a6b259c4cc355de076fbbcb235dd81b895de6d3fff4d95db7ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. 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| ispartof | Atherosclerosis, 2012-05, Vol.222 (1), p.148-153 |
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| subjects | Aged Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular cell communication Connexin40 Connexins - genetics Coronary artery disease Coronary Artery Disease - genetics Coronary heart disease endothelium Female Gap junction Gap Junction alpha-5 Protein Gene polymorphism genes genotype Heart hospitals Human Umbilical Vein Endothelial Cells Humans Hypertension Hypertension - genetics Male Medical sciences mice Middle Aged patients Plaque stability Plaque, Atherosclerotic - pathology Polymorphism, Genetic promoter regions Promoter Regions, Genetic |
| title | Lack of association between connexin40 polymorphisms and coronary artery disease |
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