Lack of association between connexin40 polymorphisms and coronary artery disease

Highlights ► Human Cx40 is expressed under its promoter A in endothelial cells. ► Cx40 promoter A polymorphisms are not associated with coronary artery disease. ► Reduction of Cx40 expression by half may not be sufficient to promote atherosclerosis.

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Bibliographische Detailangaben
Veröffentlicht in:	Atherosclerosis 2012-05, Vol.222 (1), p.148-153
Hauptverfasser:	Pfenniger, Anna, van der Laan, Sander W, Foglia, Bernard, Dunoyer-Geindre, Sylvie, Haefliger, Jacques-Antoine, Winnik, Stephan, Mach, François, Pasterkamp, Gerard, James, Richard W, Kwak, Brenda R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular cell communication Connexin40 Connexins - genetics Coronary artery disease Coronary Artery Disease - genetics Coronary heart disease endothelium Female Gap junction Gap Junction alpha-5 Protein Gene polymorphism genes genotype Heart hospitals Human Umbilical Vein Endothelial Cells Humans Hypertension Hypertension - genetics Male Medical sciences mice Middle Aged patients Plaque stability Plaque, Atherosclerotic - pathology Polymorphism, Genetic promoter regions Promoter Regions, Genetic
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Beschreibung
Zusammenfassung:	Highlights ► Human Cx40 is expressed under its promoter A in endothelial cells. ► Cx40 promoter A polymorphisms are not associated with coronary artery disease. ► Reduction of Cx40 expression by half may not be sufficient to promote atherosclerosis.
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2012.01.050