Inulin increases short-term markers for colonic fermentation similarly in healthy and hyperinsulinaemic humans

Background/Objectives: Colonic fermentation of dietary fibre produces short-chain fatty acids (SCFAs), acetate, propionate and butyrate, which may protect against type 2 diabetes by reducing serum free-fatty acids (FFAs). Since hyperinsulinaemia is associated with insulin resistance and increased di...

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Veröffentlicht in:	European journal of clinical nutrition 2011-12, Vol.65 (12), p.1279-1286
Hauptverfasser:	Fernandes, J, Vogt, J, Wolever, T M S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319 692/699/2743/137/773 692/699/2743/393 Absorption Acetates - blood Acetic acid Adult Area Under Curve Biological and medical sciences Biomarkers - metabolism Breath Tests Clinical Nutrition Colon Colon - drug effects Colon - metabolism Cross-Over Studies Development and progression Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dietary Carbohydrates - pharmacology Dietary fiber Dietary Fiber - metabolism Diets Epidemiology Fatty acids Fatty Acids, Volatile - metabolism Feeding. Feeding behavior Female Fermentation Fundamental and applied biological sciences. Psychology Glucose Glucose - metabolism Health aspects Health risks Humans Hydrogen - metabolism Hyperinsulinism - metabolism Ingestion Insulin Insulin resistance Internal Medicine Inulin Inulin - pharmacology Kinetics Male Markers Medical sciences Medicine Medicine & Public Health Metabolic Diseases Methane Methane - metabolism Nutrition research original-article Physiological aspects Propionic acid Public Health Single-Blind Method Statistical analysis Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	Background/Objectives: Colonic fermentation of dietary fibre produces short-chain fatty acids (SCFAs), acetate, propionate and butyrate, which may protect against type 2 diabetes by reducing serum free-fatty acids (FFAs). Since hyperinsulinaemia is associated with insulin resistance and increased diabetes risk, the main objective was to compare markers of colonic fermentation after acute inulin ingestion in subjects with normal (
ISSN:	0954-3007 1476-5640
DOI:	10.1038/ejcn.2011.116