Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction in Water Using Cyclodextrin as a Phase Transfer Catalyst

1,4-Disubstituted-1,2,3-triazoles were obtained in excellent yields from azides and terminal alkynes in H2O in the presence of catalytic amount of β-cyclodextrin as a phase transfer catalyst. Also, a one-pot CuAAC reaction was carried out successfully, affording 1,4-disubstituted-1,2,3-triazoles in...

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Veröffentlicht in:Journal of organic chemistry 2012-04, Vol.77 (8), p.4117-4122
Hauptverfasser: Shin, Jung-Ah, Lim, Yeong-Gweon, Lee, Kyung-Hee
Format: Artikel
Sprache:eng
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Zusammenfassung:1,4-Disubstituted-1,2,3-triazoles were obtained in excellent yields from azides and terminal alkynes in H2O in the presence of catalytic amount of β-cyclodextrin as a phase transfer catalyst. Also, a one-pot CuAAC reaction was carried out successfully, affording 1,4-disubstituted-1,2,3-triazoles in good to high yields starting from an alkyl bromide, sodium azide, and terminal alkyne.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo3000095