Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction in Water Using Cyclodextrin as a Phase Transfer Catalyst
1,4-Disubstituted-1,2,3-triazoles were obtained in excellent yields from azides and terminal alkynes in H2O in the presence of catalytic amount of β-cyclodextrin as a phase transfer catalyst. Also, a one-pot CuAAC reaction was carried out successfully, affording 1,4-disubstituted-1,2,3-triazoles in...
Gespeichert in:
Veröffentlicht in: | Journal of organic chemistry 2012-04, Vol.77 (8), p.4117-4122 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | 1,4-Disubstituted-1,2,3-triazoles were obtained in excellent yields from azides and terminal alkynes in H2O in the presence of catalytic amount of β-cyclodextrin as a phase transfer catalyst. Also, a one-pot CuAAC reaction was carried out successfully, affording 1,4-disubstituted-1,2,3-triazoles in good to high yields starting from an alkyl bromide, sodium azide, and terminal alkyne. |
---|---|
ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/jo3000095 |