Template-Assisted and Self-Activating Clicked Peptide as a Synthetic Mimic of the SH2 Domain

A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain,...

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Veröffentlicht in:ACS chemical biology 2012-04, Vol.7 (4), p.637-645
Hauptverfasser: Tanaka, Katsunori, Shirotsuki, Sanae, Iwata, Takayuki, Kageyama, Chika, Tahara, Tsuyoshi, Nozaki, Satoshi, Siwu, Eric R. O, Tamura, Satoru, Douke, Shunsuke, Murakami, Nobutoshi, Onoe, Hirotaka, Watanabe, Yasuyoshi, Fukase, Koichi
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Sprache:eng
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Zusammenfassung:A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.
ISSN:1554-8929
1554-8937
DOI:10.1021/cb2003175