Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis

The effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the pres...

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Veröffentlicht in:	Medical mycology (Oxford) 2012-05, Vol.50 (4), p.421-426
Hauptverfasser:	Schulz, Bettina, Knobloch, Mathias, Moran, Gary P., Weber, Kai, Ruhnke, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Biological Transport, Active - drug effects Candida - drug effects Doxorubicin - pharmacology Fluconazole - pharmacology Gene Expression - drug effects Gene Expression Profiling Humans Microbial Sensitivity Tests
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Zusammenfassung:	The effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.
ISSN:	1369-3786 1460-2709
DOI:	10.3109/13693786.2011.608730