Hemin/G-quadruplex simultaneously acts as NADH oxidase and HRP-mimicking DNAzyme for simple, sensitive pseudobienzyme electrochemical detection of thrombin

Hemin/G-quadruplex simultaneously acts as NADH oxidase and HRP-mimicking DNAzyme for simple, sensitive pseudobienzyme electrochemical detection of thrombin

For the first time, hemin/G-quadruplex was employed to simultaneously serve as NADH oxidase and an HRP-mimicking DNAzyme for constructing a simple and sensitive pseudobienzyme-amplifying electrochemical aptasensor for thrombin detection.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (38), p.4621-4623
Hauptverfasser: Yuan, Yali, Yuan, Ruo, Chai, Yaqin, Zhuo, Ying, Ye, Xiaoya, Gan, Xianxue, Bai, Lijuan
Format: Artikel
Sprache:eng
Schlagworte:
Biocatalysis
Biomimetic Materials - metabolism
DNA, Catalytic - metabolism
Electrochemical Techniques
G-Quadruplexes
Hemin - chemistry
Horseradish Peroxidase - metabolism
Multienzyme Complexes - metabolism
NADH, NADPH Oxidoreductases - metabolism
Thrombin - analysis
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Beschreibung
Zusammenfassung:For the first time, hemin/G-quadruplex was employed to simultaneously serve as NADH oxidase and an HRP-mimicking DNAzyme for constructing a simple and sensitive pseudobienzyme-amplifying electrochemical aptasensor for thrombin detection.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc31423a